Cargando…

The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity

Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i’s) in combination with chemotherapy have shown promising results in preclinical studies but minimal efficacy with substantial toxicity in clinical trials. To explore novel combinational str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prasad, Chandra Bhushan, Oo, Adrian, Qiu, Zhaojun, Li, Na, Singh, Deepika, Xin, Xiwen, Cho, Young-Jae, Li, Zaibo, Zhang, Xiaoli, Yan, Chunhong, Zheng, Qingfei, Shao, Jimin, Wang, Qi-En, Kim, Baek, Zhang, Junran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187419/ https://www.ncbi.nlm.nih.gov/pubmed/37205570 http://dx.doi.org/10.21203/rs.3.rs-2814118/v1

Ejemplares similares

Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine
por: Goss, Kelli L, et al.
Publicado: (2017)

Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins
por: Domkin, Vladimir, et al.
Publicado: (2014)

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246
por: Haffo, Lena, et al.
Publicado: (2018)

Corrigendum: Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins
por: Domkin, Vladimir, et al.
Publicado: (2017)

Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment
por: Bothou, Christina, et al.
Publicado: (2021)

A Functional Approach Reveals a Genetic and Physical Interaction between Ribonucleotide Reductase and CHK1 in Mammalian Cells
por: Taricani, Lorena, et al.
Publicado: (2014)

Convergent allostery in ribonucleotide reductase
por: Thomas, William C., et al.
Publicado: (2019)

The periodic table of ribonucleotide reductases
por: Ruskoski, Terry B., et al.
Publicado: (2021)

Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse
por: Brown, Anthony, et al.
Publicado: (2023)

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression
por: Selenius, Markus, et al.
Publicado: (2012)

MITF Is Regulated by Redox Signals Controlled by the Selenoprotein Thioredoxin Reductase 1
por: Kline, Chelsey D., et al.
Publicado: (2022)

Disequilibrium in the Thioredoxin Reductase-1/Thioredoxin-1 Redox Couple Is Associated with Increased T-Cell Apoptosis in Children with Autism
por: Alshehri, Samiyah, et al.
Publicado: (2023)

The tyrosyl free radical in ribonucleotide reductase.
por: Gräslund, A, et al.
Publicado: (1985)

Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function
por: Stancill, Jennifer S, et al.
Publicado: (2022)

Rational polynomial representation of ribonucleotide reductase activity
por: Radivoyevitch, Tomas, et al.
Publicado: (2005)

Ribonucleotide reductases: essential enzymes for bacterial life
por: Torrents, Eduard
Publicado: (2014)

Thioredoxin 1 and Thioredoxin Reductase 1 Redox System Is Dysregulated in Neutrophils of Subjects with Autism: In Vitro Effects of Environmental Toxicant, Methylmercury
por: Alshehri, Samiyah, et al.
Publicado: (2023)

Redox Regulation of Monodehydroascorbate Reductase by Thioredoxin y in Plastids Revealed in the Context of Water Stress
por: Vanacker, Hélène, et al.
Publicado: (2018)

Enzymatic Redox Properties and Cytotoxicity of Irreversible Nitroaromatic Thioredoxin Reductase Inhibitors in Mammalian Cells
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2023)

Thioredoxin Reductase and its Inhibitors
por: Saccoccia, Fulvio, et al.
Publicado: (2014)

Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
por: Dong, Zizheng, et al.
Publicado: (2005)

A Mechanistic Investigation of the C-Terminal Redox Motif of Thioredoxin Reductase from Plasmodium falciparum
por: Snider, Gregg W., et al.
Publicado: (2014)

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
por: Liew, Li Phing, et al.
Publicado: (2016)

Structural determinants and distribution of phosphate specificity in ribonucleotide reductases
por: Schell, Eugen, et al.
Publicado: (2021)

Ribonucleotide reductase, a novel drug target for gonorrhea
por: Narasimhan, Jana, et al.
Publicado: (2022)

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present
por: Huff, Sarah E., et al.
Publicado: (2022)

Kinetic model for reversible radical transfer in ribonucleotide reductase
por: Reinhardt, Clorice R., et al.
Publicado: (2022)

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy
por: Wijerathna, Sanath R., et al.
Publicado: (2011)

The Role of Thioredoxin Reductases in Brain Development
por: Soerensen, Jonna, et al.
Publicado: (2008)

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
por: Prigge, Justin R., et al.
Publicado: (2017)

Direct Electrochemical Analyses of a Thermophilic Thioredoxin Reductase: Interplay between Conformational Change and Redox Chemistry
por: Hamill, Michael J., et al.
Publicado: (2008)

Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase
por: Chethna, Pogakula, et al.
Publicado: (2018)

A docking model of human ribonucleotide reductase with flavin and phenosafranine
por: Priya, Panneerselvam Lakshmi, et al.
Publicado: (2009)

Biofilm Modifies Expression of Ribonucleotide Reductase Genes in Escherichia coli
por: Cendra, Maria del Mar, et al.
Publicado: (2012)

Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice
por: Ylikallio, Emil, et al.
Publicado: (2010)

The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML
por: Cook, Guerry J., et al.
Publicado: (2014)

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
por: Misko, Tessianna A., et al.
Publicado: (2019)

Acetylation regulates ribonucleotide reductase activity and cancer cell growth
por: Chen, Guo, et al.
Publicado: (2019)

Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase
por: Gaur, Kavita, et al.
Publicado: (2021)

Prognostic and Immunological Potential of Ribonucleotide Reductase Subunits in Liver Cancer
por: Yin, Xin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f79432gongarft566o5us2qj27