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Metal interactions of α-synuclein probed by NMR amide-proton exchange
The aberrant aggregation of α-synuclein (αS), a disordered protein primarily expressed in neuronal cells, is strongly associated with the underlying mechanisms of Parkinson’s disease. It is now established that αS has a weak affinity for metal ions and that these interactions alter its conformationa...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187754/ https://www.ncbi.nlm.nih.gov/pubmed/37201129 http://dx.doi.org/10.3389/fchem.2023.1167766 |