Domain tethering impacts dimerization and DNA-mediated allostery in the human transcription factor FoxP1

Transcription factors are multidomain proteins with specific DNA binding and regulatory domains. In the human FoxP subfamily (FoxP1, FoxP2, FoxP3, and FoxP4) of transcription factors, a 90 residue-long disordered region links a Leucine Zipper (ZIP)—known to form coiled-coil dimers—and a Forkhead (FK...

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Detalles Bibliográficos
Autores principales: Cruz, Perla, Paredes, Nicolás, Asela, Isabel, Kolimi, Narendar, Molina, José Alejandro, Ramírez-Sarmiento, César A., Goutam, Rajen, Huang, Gangton, Medina, Exequiel, Sanabria, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2023
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188207/
https://www.ncbi.nlm.nih.gov/pubmed/37184020
http://dx.doi.org/10.1063/5.0138782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188207/
https://www.ncbi.nlm.nih.gov/pubmed/37184020
http://dx.doi.org/10.1063/5.0138782

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