A phase 1 first‐in‐human study of GS‐0189, an anti‐signal regulatory protein alpha (SIRPα) monoclonal antibody, in patients with relapsed/refractory (R/R) non‐Hodgkin lymphoma (NHL)

Signal regulatory protein alpha (SIRPα) is the receptor for cluster of differentiation (CD)47, a potent “don't eat me” signal for macrophages. Disruption of CD47‐SIRPα signaling in the presence of prophagocytic signals can lead to enhanced phagocytosis of tumor cells, resulting in a direct anti...

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Detalles Bibliográficos
Autores principales: Narkhede, Mayur, Bartlett, Nancy L., Ibrahimi, Sami, Popplewell, Leslie, Seto, Anna, Bates, Jamie, Lee, Yeonju, Ganti, Vaishnavi, Han, Ling, Chen, Tianling, Patel, Manish R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Haematologic Malignancy ‐ Lymphoid
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188468/
https://www.ncbi.nlm.nih.gov/pubmed/37206279
http://dx.doi.org/10.1002/jha2.687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188468/
https://www.ncbi.nlm.nih.gov/pubmed/37206279
http://dx.doi.org/10.1002/jha2.687

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