Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities

Life science studies involving clustered regularly interspaced short palindromic repeat (CRISPR) editing generally apply the best-performing guide RNA (gRNA) for a gene of interest. Computational models are combined with massive experimental quantification on synthetic gRNA-target libraries to accur...

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Detalles Bibliográficos
Autores principales: Zhang, Heng, Yan, Jianfeng, Lu, Zhike, Zhou, Yangfan, Zhang, Qingfeng, Cui, Tingting, Li, Yini, Chen, Hui, Ma, Lijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188485/
https://www.ncbi.nlm.nih.gov/pubmed/37193681
http://dx.doi.org/10.1038/s41421-023-00549-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188485/
https://www.ncbi.nlm.nih.gov/pubmed/37193681
http://dx.doi.org/10.1038/s41421-023-00549-9

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