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Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities
Life science studies involving clustered regularly interspaced short palindromic repeat (CRISPR) editing generally apply the best-performing guide RNA (gRNA) for a gene of interest. Computational models are combined with massive experimental quantification on synthetic gRNA-target libraries to accur...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Nature Singapore
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188485/ https://www.ncbi.nlm.nih.gov/pubmed/37193681 http://dx.doi.org/10.1038/s41421-023-00549-9 |