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GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator
Cyclic phosphatidic acid (cPA) is a lipid mediator, which regulates adipogenic differentiation and glucose homeostasis by suppressing nuclear peroxisome proliferator-activated receptor γ (PPARγ). Glycerophosphodiesterase 7 (GDE7) is a Ca(2+)-dependent lysophospholipase D that localizes in the endopl...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188492/ https://www.ncbi.nlm.nih.gov/pubmed/37193762 http://dx.doi.org/10.1038/s42003-023-04900-4 |