Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer

Non-small cell lung carcinomas (NSCLC) are the predominant form of lung malignancy and the reason for the highest number of cancer-related deaths. Widespread deregulation of Akt, a serine/threonine kinase, has been reported in NSCLC. Allosteric Akt inhibitors bind in the space separating the Pleckst...

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Detalles Bibliográficos
Autores principales: Baby, Krishnaprasad, Maity, Swastika, Mehta, Chetan Hasmukh, Nayak, Usha Y., Shenoy, Gautham G., Pai, Karkala Sreedhara Ranganath, Harikumar, Kuzhuvelil B., Nayak, Yogendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188557/
https://www.ncbi.nlm.nih.gov/pubmed/37193898
http://dx.doi.org/10.1038/s41598-023-35122-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188557/
https://www.ncbi.nlm.nih.gov/pubmed/37193898
http://dx.doi.org/10.1038/s41598-023-35122-7

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