Quaternization of high molecular weight chitosan for increasing intestinal drug absorption using Caco-2 cells as an in vitro intestinal model

Potential use of a quaternized chitosan (MW 600 kDa) with 65% of 3-chloro-2-hydroxypropyltrimethylammonium (600-HPTChC(65)) as an absorptive enhancer was investigated in Caco-2 monolayers. 600-HPTChC(65) (0.005% w/v) quickly reduced transepithelial electrical resistance (TEER) to the maximum level i...

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Detalles Bibliográficos
Autores principales: Wongwanakul, Ratjika, Aueviriyavit, Sasitorn, Furihata, Tomomi, Gonil, Pattarapond, Sajomsang, Warayuth, Maniratanachote, Rawiwan, Jianmongkol, Suree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188607/
https://www.ncbi.nlm.nih.gov/pubmed/37193745
http://dx.doi.org/10.1038/s41598-023-34888-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188607/
https://www.ncbi.nlm.nih.gov/pubmed/37193745
http://dx.doi.org/10.1038/s41598-023-34888-0

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