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Quaternization of high molecular weight chitosan for increasing intestinal drug absorption using Caco-2 cells as an in vitro intestinal model
Potential use of a quaternized chitosan (MW 600 kDa) with 65% of 3-chloro-2-hydroxypropyltrimethylammonium (600-HPTChC(65)) as an absorptive enhancer was investigated in Caco-2 monolayers. 600-HPTChC(65) (0.005% w/v) quickly reduced transepithelial electrical resistance (TEER) to the maximum level i...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188607/ https://www.ncbi.nlm.nih.gov/pubmed/37193745 http://dx.doi.org/10.1038/s41598-023-34888-0 |