Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study

BACKGROUND: This study aims to assess the prevalence of atrial cardiomyopathy (ACM) in patients with new-onset metabolic syndrome (MetS) and investigate whether ACM could be a predictor of hospital admission for cardiovascular (CV) events. METHODS: Patients with MetS who were free of clinically prov...

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Autores principales: Wali, Rohbaiz, Wang, Xinying, Li, Chenglin, Yang, Heng, Liu, Fei, Sama, Salah D., Bai, Lan, Lee, Sharen, Hidru, Tesfaldet H., Yang, Xiaolei, Xia, Yunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188925/
https://www.ncbi.nlm.nih.gov/pubmed/37206097
http://dx.doi.org/10.3389/fcvm.2023.1162886
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author Wali, Rohbaiz
Wang, Xinying
Li, Chenglin
Yang, Heng
Liu, Fei
Sama, Salah D.
Bai, Lan
Lee, Sharen
Hidru, Tesfaldet H.
Yang, Xiaolei
Xia, Yunlong
author_facet Wali, Rohbaiz
Wang, Xinying
Li, Chenglin
Yang, Heng
Liu, Fei
Sama, Salah D.
Bai, Lan
Lee, Sharen
Hidru, Tesfaldet H.
Yang, Xiaolei
Xia, Yunlong
author_sort Wali, Rohbaiz
collection PubMed
description BACKGROUND: This study aims to assess the prevalence of atrial cardiomyopathy (ACM) in patients with new-onset metabolic syndrome (MetS) and investigate whether ACM could be a predictor of hospital admission for cardiovascular (CV) events. METHODS: Patients with MetS who were free of clinically proven atrial fibrillation and other CV diseases (CVDs) at baseline were included in the present study. The prevalence of ACM was compared between MetS patients with and without left ventricular hypertrophy (LVH). The time to first hospital admission for a CV event between subgroups was assessed using the Cox proportional hazard model. RESULTS: A total of 15,528 MetS patients were included in the final analysis. Overall, LVH patients accounted for 25.6% of all newly diagnosed MetS patients. ACM occurred in 52.9% of the cohort and involved 74.8% of LVH patients. Interestingly, a significant percentage of ACM patients (45.4%) experienced MetS without LVH. After 33.2 ± 20.6 months of follow-up, 7,468 (48.1%) patients had a history of readmission due to CV events. Multivariable Cox regression analysis revealed that ACM was associated with an increased risk of admission for CVDs in the MetS patients with LVH [hazard ratio (HR), 1.29; 95% confidence interval (CI), 1.142–1.458; P < 0.001]. Likewise, ACM was found to be independently associated with hospital readmission due to CVD-related events in MetS patients without LVH (HR, 1.175; 95% CI, 1.105–1.250; P < 0.001). CONCLUSION: ACM is a marker of early myocardial remodeling and predicts hospitalization for CV events in patients with MetS.
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spelling pubmed-101889252023-05-18 Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study Wali, Rohbaiz Wang, Xinying Li, Chenglin Yang, Heng Liu, Fei Sama, Salah D. Bai, Lan Lee, Sharen Hidru, Tesfaldet H. Yang, Xiaolei Xia, Yunlong Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: This study aims to assess the prevalence of atrial cardiomyopathy (ACM) in patients with new-onset metabolic syndrome (MetS) and investigate whether ACM could be a predictor of hospital admission for cardiovascular (CV) events. METHODS: Patients with MetS who were free of clinically proven atrial fibrillation and other CV diseases (CVDs) at baseline were included in the present study. The prevalence of ACM was compared between MetS patients with and without left ventricular hypertrophy (LVH). The time to first hospital admission for a CV event between subgroups was assessed using the Cox proportional hazard model. RESULTS: A total of 15,528 MetS patients were included in the final analysis. Overall, LVH patients accounted for 25.6% of all newly diagnosed MetS patients. ACM occurred in 52.9% of the cohort and involved 74.8% of LVH patients. Interestingly, a significant percentage of ACM patients (45.4%) experienced MetS without LVH. After 33.2 ± 20.6 months of follow-up, 7,468 (48.1%) patients had a history of readmission due to CV events. Multivariable Cox regression analysis revealed that ACM was associated with an increased risk of admission for CVDs in the MetS patients with LVH [hazard ratio (HR), 1.29; 95% confidence interval (CI), 1.142–1.458; P < 0.001]. Likewise, ACM was found to be independently associated with hospital readmission due to CVD-related events in MetS patients without LVH (HR, 1.175; 95% CI, 1.105–1.250; P < 0.001). CONCLUSION: ACM is a marker of early myocardial remodeling and predicts hospitalization for CV events in patients with MetS. Frontiers Media S.A. 2023-05-03 /pmc/articles/PMC10188925/ /pubmed/37206097 http://dx.doi.org/10.3389/fcvm.2023.1162886 Text en © 2023 Wali, Wang, Li, Yang, Liu, Sama, Bai, Lee, Hidru, Yang and Xia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wali, Rohbaiz
Wang, Xinying
Li, Chenglin
Yang, Heng
Liu, Fei
Sama, Salah D.
Bai, Lan
Lee, Sharen
Hidru, Tesfaldet H.
Yang, Xiaolei
Xia, Yunlong
Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
title Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
title_full Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
title_fullStr Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
title_full_unstemmed Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
title_short Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
title_sort early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188925/
https://www.ncbi.nlm.nih.gov/pubmed/37206097
http://dx.doi.org/10.3389/fcvm.2023.1162886
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