Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

Staphylococcus aureus superantigens (SAgs) such as staphylococcal enterotoxin A (SEA) and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory cytokines, thus causing toxic shock and sepsis. Here we used a recently released artificial intelligence-based algorithm to b...

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Detalles Bibliográficos
Autores principales: Kunkl, Martina, Amormino, Carola, Spallotta, Francesco, Caristi, Silvana, Fiorillo, Maria Teresa, Paiardini, Alessandro, Kaempfer, Raymond, Tuosto, Loretta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189049/
https://www.ncbi.nlm.nih.gov/pubmed/37207220
http://dx.doi.org/10.3389/fimmu.2023.1170821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189049/
https://www.ncbi.nlm.nih.gov/pubmed/37207220
http://dx.doi.org/10.3389/fimmu.2023.1170821

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