Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins

Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets. Here, we use DEL screening against bromodomain and extra-term...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Seoyeon, Kim, Hwa-Ryeon, Shin, June-Ha, Son, Min-Hee, Lee, In-Hyun, Roe, Jae-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189352/
https://www.ncbi.nlm.nih.gov/pubmed/37207130
http://dx.doi.org/10.1016/j.omtn.2023.04.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189352/
https://www.ncbi.nlm.nih.gov/pubmed/37207130
http://dx.doi.org/10.1016/j.omtn.2023.04.023

Ejemplares similares