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Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins
Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets. Here, we use DEL screening against bromodomain and extra-term...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189352/ https://www.ncbi.nlm.nih.gov/pubmed/37207130 http://dx.doi.org/10.1016/j.omtn.2023.04.023 |