Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs

The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a central regulator of learning and memory, which poses a problem for targeting it therapeutically. Indeed, our study supports prior conclusions that long-term interference with CaMKII signaling can erase pre-formed memories. By contrast,...

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Detalles Bibliográficos
Autores principales: Rumian, Nicole L., Brown, Carolyn Nicole, Hendry-Hofer, Tara B., Rossetti, Thomas, Orfila, James E., Tullis, Jonathan E., Dwoskin, Linda P., Buonarati, Olivia R., Lisman, John E., Quillinan, Nidia, Herson, Paco S., Bebarta, Vikhyat S., Bayer, K. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189404/
https://www.ncbi.nlm.nih.gov/pubmed/37037305
http://dx.doi.org/10.1016/j.jbc.2023.104693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189404/
https://www.ncbi.nlm.nih.gov/pubmed/37037305
http://dx.doi.org/10.1016/j.jbc.2023.104693

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