Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets

The exquisite specificity, natural biological functions, and favorable development properties of antibodies make them highly effective agents as drugs. Monoclonal antibodies are particularly strong as inhibitors of systemically accessible targets where trough-level concentrations can sustain full ta...

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Detalles Bibliográficos
Autores principales: Romei, Matthew G., Leonard, Brandon, Kim, Ingrid, Kim, Hok Seon, Lazar, Greg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189407/
https://www.ncbi.nlm.nih.gov/pubmed/37031819
http://dx.doi.org/10.1016/j.jbc.2023.104685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189407/
https://www.ncbi.nlm.nih.gov/pubmed/37031819
http://dx.doi.org/10.1016/j.jbc.2023.104685

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