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Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets
The exquisite specificity, natural biological functions, and favorable development properties of antibodies make them highly effective agents as drugs. Monoclonal antibodies are particularly strong as inhibitors of systemically accessible targets where trough-level concentrations can sustain full ta...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189407/ https://www.ncbi.nlm.nih.gov/pubmed/37031819 http://dx.doi.org/10.1016/j.jbc.2023.104685 |