GSK-3484862 targets DNMT1 for degradation in cells

Maintenance of genomic methylation patterns at DNA replication forks by DNMT1 is the key to faithful mitotic inheritance. DNMT1 is often overexpressed in cancer cells and the DNA hypomethylating agents azacytidine and decitabine are currently used in the treatment of hematologic malignancies. Howeve...

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Detalles Bibliográficos
Autores principales: Chen, Qin, Liu, Bigang, Zeng, Yang, Hwang, Jee Won, Dai, Nan, Corrêa, Ivan R, Estecio, Marcos R, Zhang, Xing, Santos, Margarida A, Chen, Taiping, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189803/
https://www.ncbi.nlm.nih.gov/pubmed/37206360
http://dx.doi.org/10.1093/narcan/zcad022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189803/
https://www.ncbi.nlm.nih.gov/pubmed/37206360
http://dx.doi.org/10.1093/narcan/zcad022

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