Cargando…

GSK-3484862 targets DNMT1 for degradation in cells

Maintenance of genomic methylation patterns at DNA replication forks by DNMT1 is the key to faithful mitotic inheritance. DNMT1 is often overexpressed in cancer cells and the DNA hypomethylating agents azacytidine and decitabine are currently used in the treatment of hematologic malignancies. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Qin, Liu, Bigang, Zeng, Yang, Hwang, Jee Won, Dai, Nan, Corrêa, Ivan R, Estecio, Marcos R, Zhang, Xing, Santos, Margarida A, Chen, Taiping, Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189803/ https://www.ncbi.nlm.nih.gov/pubmed/37206360 http://dx.doi.org/10.1093/narcan/zcad022

Ejemplares similares

DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
por: Veland, Nicolas, et al.
Publicado: (2019)

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L
por: Jurkowska, Renata Z., et al.
Publicado: (2008)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
por: Van Emburgh, Beth O., et al.
Publicado: (2011)

Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression
por: Estève, Pierre-Olivier, et al.
Publicado: (2016)

SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
por: Zhang, Huifang, et al.
Publicado: (2019)

Targeting of 5-aza-2′-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
por: Patel, Katan, et al.
Publicado: (2010)

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
por: Felle, Max, et al.
Publicado: (2011)

Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
por: Stepper, Peter, et al.
Publicado: (2017)

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail
por: Zhang, Yingying, et al.
Publicado: (2010)

Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island
por: Zhang, Yan, et al.
Publicado: (2012)

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing
por: O’Geen, Henriette, et al.
Publicado: (2022)

Transient DNMT1 suppression reveals hidden heritable marks in the genome
por: McGraw, Serge, et al.
Publicado: (2015)

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells
por: Jin, Chunlei, et al.
Publicado: (2014)

Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
por: Dukatz, Michael, et al.
Publicado: (2020)

Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling
por: Schneider, Katrin, et al.
Publicado: (2013)

On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase
por: Adam, Sabrina, et al.
Publicado: (2023)

ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing
por: Gatto, Sole, et al.
Publicado: (2017)

Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation
por: Deplus, Rachel, et al.
Publicado: (2014)

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation
por: Thompson, Joyce J, et al.
Publicado: (2018)

Dnmt1 binds and represses genomic retroelements via DNA methylation in mouse early embryos
por: Min, Byungkuk, et al.
Publicado: (2020)

The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation
por: Recalde, Miriam, et al.
Publicado: (2021)

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
por: Clements, Eriko G., et al.
Publicado: (2012)

Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP
por: Zhang, Yuxia, et al.
Publicado: (2012)

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context
por: Espada, Jesús, et al.
Publicado: (2011)

GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair
por: Lee, Bongyong, et al.
Publicado: (2012)

A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association
por: Han, Mengmeng, et al.
Publicado: (2020)

GSK3β is a negative regulator of the transcriptional coactivator MAML1
por: Saint Just Ribeiro, Mariana, et al.
Publicado: (2009)

A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA
por: Shen, Li, et al.
Publicado: (2010)

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts
por: Zhang, Donghong, et al.
Publicado: (2017)

Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA
por: Hashimoto, Hideharu, et al.
Publicado: (2015)

GSK3β-SCF(FBXW7α) mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
por: Garvin, Alexander J, et al.
Publicado: (2019)

Structural basis of specific DNA binding by the transcription factor ZBTB24
por: Ren, Ren, et al.
Publicado: (2019)

The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells
por: Azevedo Portilho, Nathalia, et al.
Publicado: (2021)

Gcn5-mediated Rph1 acetylation regulates its autophagic degradation under DNA damage stress
por: Li, Feng, et al.
Publicado: (2017)

P-TEFb is degraded by Siah1/2 in quiescent cells
por: Huang, Fang, et al.
Publicado: (2022)

AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation
por: Lee, Kyung-Ha, et al.
Publicado: (2014)

Nuclear mRNA degradation tunes the gain of the unfolded protein response in Saccharomyces cerevisiae
por: Sarkar, Debasish, et al.
Publicado: (2018)

Nuclear Ccr4-Not mediates the degradation of telomeric and transposon transcripts at chromatin in the Drosophila germline
por: Kordyukova, Maria, et al.
Publicado: (2020)

The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus
por: Rochat, Tatiana, et al.
Publicado: (2018)

The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4
por: Begley, Victoria, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jh5sceeph5dm39eo8kaui5fk8c