A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy

We report the self-assembly of amphiphilic BDQ photosensitizers into lysosome-targeting nanophotosensitizer BDQ-NP for highly effective photodynamic therapy (PDT). Molecular dynamics simulation, live cell imaging, and subcellular colocalization studies showed that BDQ strongly incorporated into lyso...

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Detalles Bibliográficos
Autores principales: Li, Youyou, Han, Wenbo, Gong, Deyan, Luo, Taokun, Fan, Yingjie, Mao, Jianming, Qin, Wenwu, Lin, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189857/
https://www.ncbi.nlm.nih.gov/pubmed/37206384
http://dx.doi.org/10.1039/d3sc00455d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189857/
https://www.ncbi.nlm.nih.gov/pubmed/37206384
http://dx.doi.org/10.1039/d3sc00455d

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