Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities

Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer’s disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite outgrowth. This study replaced phenothiazine moiety with p...

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Detalles Bibliográficos
Autores principales: Chu, Jung-Chun, Tseng, Hui-Ju, Lee, Sung-Bau, Hsu, Kai-Cheng, Hsin, Ling-Wei, Liang, Ru-Hao, Lin, Tony Eight, Gao, Nain-Chu, Chen, Liang-Chieh, Lu, Wan-Hsun, Wang, Andrew H.-J, Huang, Wei-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190190/
https://www.ncbi.nlm.nih.gov/pubmed/37190931
http://dx.doi.org/10.1080/14756366.2023.2212326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190190/
https://www.ncbi.nlm.nih.gov/pubmed/37190931
http://dx.doi.org/10.1080/14756366.2023.2212326

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