Oleic Acid Dissolves cGAS–DNA Phase Separation to Inhibit Immune Surveillance

Phase separation (PS) is a fundamental principle in diverse life processes including immunosurveillance. Despite numerous studies on PS, little is known about its dissolution. Here, it is shown that oleic acid (OA) dissolves the cyclic GMP–AMP synthase (cGAS)–deoxyribonucleic acid (DNA) PS and inhib...

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Detalles Bibliográficos
Autores principales: Wang, Lina, Liu, Qiaoling, Wang, Na, Li, Siru, Bian, Wei, Sun, Zhen, Wang, Lulu, Wang, Li, Liu, Caigang, Song, Chengli, Liu, Quentin, Yang, Qingkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190586/
https://www.ncbi.nlm.nih.gov/pubmed/36950761
http://dx.doi.org/10.1002/advs.202206820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190586/
https://www.ncbi.nlm.nih.gov/pubmed/36950761
http://dx.doi.org/10.1002/advs.202206820

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