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Bacillus subtilis encodes a discrete flap endonuclease that cleaves RNA-DNA hybrids
The current model for Okazaki fragment maturation in bacteria invokes RNA cleavage by RNase H, followed by strand displacement synthesis and 5′ RNA flap removal by DNA polymerase I (Pol I). RNA removal by Pol I is thought to occur through the 5′-3′ flap endo/exonuclease (FEN) domain, located in the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191290/ https://www.ncbi.nlm.nih.gov/pubmed/37146086 http://dx.doi.org/10.1371/journal.pgen.1010585 |