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Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate
Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W. bancrofti and additional cases by the worms B. malayi and B. timori. Dihydrofolate reductase (DHFR) is an established target in the treatment of can...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191325/ https://www.ncbi.nlm.nih.gov/pubmed/37104530 http://dx.doi.org/10.1371/journal.pntd.0011303 |