Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate

Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W. bancrofti and additional cases by the worms B. malayi and B. timori. Dihydrofolate reductase (DHFR) is an established target in the treatment of can...

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Detalles Bibliográficos
Autores principales: Lange, Keith, Frey, Kathleen M., Eck, Tyler, Janson, Cheryl A., Gubler, Ueli, Goodey, Nina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191325/
https://www.ncbi.nlm.nih.gov/pubmed/37104530
http://dx.doi.org/10.1371/journal.pntd.0011303

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