Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage

Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how bilirubin worsens outcomes remains mysterious. We report that post-, but not pre-, stroke bilirubin levels among inpatients scale with infarct volume. In mouse models, bilirubin increases neuronal excitability an...

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Detalles Bibliográficos
Autores principales: Liu, Han-Wei, Gong, Li-Na, Lai, Ke, Yu, Xia-Fei, Liu, Zhen-Qi, Li, Ming-Xian, Yin, Xin-Lu, Liang, Min, Shi, Hao-Song, Jiang, Lin-Hua, Yang, Wei, Shi, Hai-Bo, Wang, Lu-Yang, Yin, Shan-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191619/
https://www.ncbi.nlm.nih.gov/pubmed/36921602
http://dx.doi.org/10.1016/j.neuron.2023.02.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191619/
https://www.ncbi.nlm.nih.gov/pubmed/36921602
http://dx.doi.org/10.1016/j.neuron.2023.02.022

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