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Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage
Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how bilirubin worsens outcomes remains mysterious. We report that post-, but not pre-, stroke bilirubin levels among inpatients scale with infarct volume. In mouse models, bilirubin increases neuronal excitability an...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191619/ https://www.ncbi.nlm.nih.gov/pubmed/36921602 http://dx.doi.org/10.1016/j.neuron.2023.02.022 |