Novel tool to quantify with single-cell resolution the number of incoming AAV genomes co-expressed in the mouse nervous system

Adeno-associated viral (AAV) vectors are an established and safe gene delivery tool to target the nervous system. However, the payload capacity of <4.9 kb limits the transfer of large or multiple genes. Oversized payloads could be delivered by fragmenting the transgenes into separate AAV capsids...

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Detalles Bibliográficos
Autores principales: Maturana, Carola J., Verpeut, Jessica L., Kooshkbaghi, Mahdi, Engel, Esteban A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191834/
https://www.ncbi.nlm.nih.gov/pubmed/34176926
http://dx.doi.org/10.1038/s41434-021-00272-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191834/
https://www.ncbi.nlm.nih.gov/pubmed/34176926
http://dx.doi.org/10.1038/s41434-021-00272-8

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