Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation

Acute promyelocytic leukemia (APL) is an aggressive subtype of acute myeloid leukemia (AML) in which the PML/RARα fusion protein exerts oncogenic activities by recruiting repressive complexes to the promoter of specific target genes. Other epigenetic perturbations, as alterations of histone H3 lysin...

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Detalles Bibliográficos
Autores principales: Amatori, Stefano, Persico, Giuseppe, Cantatore, Francesco, Rusin, Martina, Formica, Mauro, Giorgi, Luca, Macedi, Eleonora, Casciaro, Francesca, Errico Provenzano, Alfredo, Gambardella, Stefano, Noberini, Roberta, Bonaldi, Tiziana, Fusi, Vieri, Giorgio, Marco, Fanelli, Mirco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191840/
https://www.ncbi.nlm.nih.gov/pubmed/36536122
http://dx.doi.org/10.1038/s41417-022-00576-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191840/
https://www.ncbi.nlm.nih.gov/pubmed/36536122
http://dx.doi.org/10.1038/s41417-022-00576-w

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