Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives

A carboxylic acid, an aldehyde, and an isonitrile were combined in a single step (Passerini reaction) under mechanochemical activation to produce several α‐acyloxycarboxamide derivatives in high to excellent yields within 15 min of milling. Mechanochemistry, when combined with the diversity provided...

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Detalles Bibliográficos
Autores principales: Salami, Sodeeq Aderotimi, Safari, Justin Bazibuhe, Smith, Vincent J., Krause, Rui W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191865/
https://www.ncbi.nlm.nih.gov/pubmed/37198143
http://dx.doi.org/10.1002/open.202200268
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author Salami, Sodeeq Aderotimi
Safari, Justin Bazibuhe
Smith, Vincent J.
Krause, Rui W. M.
author_facet Salami, Sodeeq Aderotimi
Safari, Justin Bazibuhe
Smith, Vincent J.
Krause, Rui W. M.
author_sort Salami, Sodeeq Aderotimi
collection PubMed
description A carboxylic acid, an aldehyde, and an isonitrile were combined in a single step (Passerini reaction) under mechanochemical activation to produce several α‐acyloxycarboxamide derivatives in high to excellent yields within 15 min of milling. Mechanochemistry, when combined with the diversity provided by multicomponent reactions, enables the efficient synthesis of the target compounds, with great atom economy, shorter reaction times, and experimental simplicity. The method allows for the rapid production of a vast library of complex compounds from a limited number of substrates.
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spelling pubmed-101918652023-05-19 Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives Salami, Sodeeq Aderotimi Safari, Justin Bazibuhe Smith, Vincent J. Krause, Rui W. M. ChemistryOpen Research Articles A carboxylic acid, an aldehyde, and an isonitrile were combined in a single step (Passerini reaction) under mechanochemical activation to produce several α‐acyloxycarboxamide derivatives in high to excellent yields within 15 min of milling. Mechanochemistry, when combined with the diversity provided by multicomponent reactions, enables the efficient synthesis of the target compounds, with great atom economy, shorter reaction times, and experimental simplicity. The method allows for the rapid production of a vast library of complex compounds from a limited number of substrates. John Wiley and Sons Inc. 2023-05-17 /pmc/articles/PMC10191865/ /pubmed/37198143 http://dx.doi.org/10.1002/open.202200268 Text en © 2023 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Salami, Sodeeq Aderotimi
Safari, Justin Bazibuhe
Smith, Vincent J.
Krause, Rui W. M.
Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives
title Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives
title_full Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives
title_fullStr Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives
title_full_unstemmed Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives
title_short Mechanochemically‐Assisted Passerini Reactions: A Practical and Convenient Method for the Synthesis of Novel α‐Acyloxycarboxamide Derivatives
title_sort mechanochemically‐assisted passerini reactions: a practical and convenient method for the synthesis of novel α‐acyloxycarboxamide derivatives
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191865/
https://www.ncbi.nlm.nih.gov/pubmed/37198143
http://dx.doi.org/10.1002/open.202200268
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