Not just protons: Chloride also activates lysosomal acidic hydrolases

Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol. https://doi.org/10.1083/jcb.202210063) report that hydrolase activation also requir...

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Detalles Bibliográficos
Autores principales: Feng, Xinghua, Liu, Siyu, Xu, Haoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191866/
https://www.ncbi.nlm.nih.gov/pubmed/37191899
http://dx.doi.org/10.1083/jcb.202305007
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author Feng, Xinghua
Liu, Siyu
Xu, Haoxing
author_facet Feng, Xinghua
Liu, Siyu
Xu, Haoxing
author_sort Feng, Xinghua
collection PubMed
description Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol. https://doi.org/10.1083/jcb.202210063) report that hydrolase activation also requires high intralysosomal Cl(−), which is established by the lysosomal Cl(−)/H(+) exchanger ClC-7.
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spelling pubmed-101918662023-11-16 Not just protons: Chloride also activates lysosomal acidic hydrolases Feng, Xinghua Liu, Siyu Xu, Haoxing J Cell Biol Spotlight Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol. https://doi.org/10.1083/jcb.202210063) report that hydrolase activation also requires high intralysosomal Cl(−), which is established by the lysosomal Cl(−)/H(+) exchanger ClC-7. Rockefeller University Press 2023-05-16 /pmc/articles/PMC10191866/ /pubmed/37191899 http://dx.doi.org/10.1083/jcb.202305007 Text en © 2023 Feng et al. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Feng, Xinghua
Liu, Siyu
Xu, Haoxing
Not just protons: Chloride also activates lysosomal acidic hydrolases
title Not just protons: Chloride also activates lysosomal acidic hydrolases
title_full Not just protons: Chloride also activates lysosomal acidic hydrolases
title_fullStr Not just protons: Chloride also activates lysosomal acidic hydrolases
title_full_unstemmed Not just protons: Chloride also activates lysosomal acidic hydrolases
title_short Not just protons: Chloride also activates lysosomal acidic hydrolases
title_sort not just protons: chloride also activates lysosomal acidic hydrolases
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191866/
https://www.ncbi.nlm.nih.gov/pubmed/37191899
http://dx.doi.org/10.1083/jcb.202305007
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