The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain

Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer’s disease (AD). However, the molecular architecture of amyloid plaques in the context of fresh mammalian brain tissue is unknown. Here, using cryogenic correlated light and electron tomography we report the in situ molecular architec...

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Detalles Bibliográficos
Autores principales: Leistner, Conny, Wilkinson, Martin, Burgess, Ailidh, Lovatt, Megan, Goodbody, Stanley, Xu, Yong, Deuchars, Susan, Radford, Sheena E., Ranson, Neil A., Frank, René A. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192217/
https://www.ncbi.nlm.nih.gov/pubmed/37198197
http://dx.doi.org/10.1038/s41467-023-38495-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192217/
https://www.ncbi.nlm.nih.gov/pubmed/37198197
http://dx.doi.org/10.1038/s41467-023-38495-5

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