Structural and functional analyses of the echinomycin resistance conferring protein Ecm16 from Streptomyces lasalocidi

Echinomycin is a natural product DNA bisintercalator antibiotic. The echinomycin biosynthetic gene cluster in Streptomyces lasalocidi includes a gene encoding the self-resistance protein Ecm16. Here, we present the 2.0 Å resolution crystal structure of Ecm16 bound to adenosine diphosphate. The struc...

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Detalles Bibliográficos
Autores principales: Gade, Priyanka, Erlandson, Amanda, Ullah, Anwar, Chen, Xi, Mathews, Irimpan I., Mera, Paola E., Kim, Chu-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192343/
https://www.ncbi.nlm.nih.gov/pubmed/37198233
http://dx.doi.org/10.1038/s41598-023-34437-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192343/
https://www.ncbi.nlm.nih.gov/pubmed/37198233
http://dx.doi.org/10.1038/s41598-023-34437-9

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