SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption

The mechanistic regulation of bone mass in aged animals is poorly understood. In this study, we examined the role of SIRT6, a longevity-associated factor, in osteocytes, using mice lacking Sirt6 in Dmp-1-expressing cells (cKO mice) and the MLO-Y4 osteocyte-like cell line. cKO mice exhibited increase...

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Detalles Bibliográficos
Autores principales: Aobulikasimu, Alkebaier, Liu, Tao, Piao, Jinying, Sato, Shingo, Ochi, Hiroki, Okawa, Atsushi, Tsuji, Kunikazu, Asou, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192395/
https://www.ncbi.nlm.nih.gov/pubmed/37198221
http://dx.doi.org/10.1038/s41598-023-33297-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192395/
https://www.ncbi.nlm.nih.gov/pubmed/37198221
http://dx.doi.org/10.1038/s41598-023-33297-7

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