Virus-like particle-based delivery of Cas9/guide RNA ribonucleoprotein efficiently edits the brachyury gene and inhibits chordoma growth in vivo

PURPOSE: Chordoma is a rare and aggressive bone cancer driven by the developmental transcription factor brachyury. Efforts to target brachyury are hampered by the absence of ligand-accessible small-molecule binding pockets. Genome editing with CRISPR systems provides an unprecedented opportunity to...

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Detalles Bibliográficos
Autores principales: Hu, Yunping, Lu, Baisong, Deng, Zhiyong, Xing, Fei, Hsu, Wesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192467/
https://www.ncbi.nlm.nih.gov/pubmed/37198417
http://dx.doi.org/10.1007/s12672-023-00680-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192467/
https://www.ncbi.nlm.nih.gov/pubmed/37198417
http://dx.doi.org/10.1007/s12672-023-00680-9

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