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The benefit of co-targeting PARP-1 and c-Met on the efficacy of radiotherapy in wild type BRAF melanoma

Melanoma is known to be a radioresistant cancer. Melanoma radioresistance can be due to several factors such as pigmentation, antioxidant defenses and high Deoxyribonucleic acid (DNA) repair efficacy. However, irradiation induces intracellular translocation of RTKs, including cMet, which regulates r...

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Detalles Bibliográficos
Autores principales: Sabbah, Malak, Najem, Ahmad, Vanderkerkhove, Christophe, Kert, Fabien, Jourani, Younes, Journe, Fabrice, Awada, Ahmad, Van Gestel, Dirk, Ghanem, Ghanem E., Krayem, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192576/
https://www.ncbi.nlm.nih.gov/pubmed/37215708
http://dx.doi.org/10.3389/fmed.2023.1149918