On a mechanistic impact of transmembrane tetramerization in the pathological activation of RTKs

Constitutive activation of receptor tyrosine kinases (RTKs) via different mutations has a strong impact on the development of severe human disorders, including cancer. Here we propose a putative activation scenario of RTKs, whereby transmembrane (TM) mutations can also promote higher-order oligomeri...

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Detalles Bibliográficos
Autores principales: Polyansky, Anton A., Efremov, Roman G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192832/
https://www.ncbi.nlm.nih.gov/pubmed/37216019
http://dx.doi.org/10.1016/j.csbj.2023.04.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192832/
https://www.ncbi.nlm.nih.gov/pubmed/37216019
http://dx.doi.org/10.1016/j.csbj.2023.04.021

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