TCR T cells overexpressing c-Jun have better functionality with improved tumor infiltration and persistence in hepatocellular carcinoma

BACKGROUND: The overall 5-year survival rate of hepatocellular carcinoma (HCC), a major form of liver cancer, is merely 20%, underscoring the need for more effective therapies. We recently identified T cell receptors (TCR) specific for the HLA-A2/alpha fetoprotein amino acids 158-166 (AFP(158)) and...

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Detalles Bibliográficos
Autores principales: Hussein, Mohamed S., Li, Qi, Mao, Rui, Peng, Yibing, He, Yukai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192869/
https://www.ncbi.nlm.nih.gov/pubmed/37215108
http://dx.doi.org/10.3389/fimmu.2023.1114770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192869/
https://www.ncbi.nlm.nih.gov/pubmed/37215108
http://dx.doi.org/10.3389/fimmu.2023.1114770

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