Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

Inflammation driven by DNA sensors is now understood to be important to disease pathogenesis. Here, we describe new inhibitors of DNA sensing, primarily of the inflammasome forming sensor AIM2. Biochemistry and molecular modeling has revealed 4-sulfonic calixarenes as potent inhibitors of AIM2 that...

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Detalles Bibliográficos
Autores principales: Green, Jack P., El-Sharkawy, Lina Y., Roth, Stefan, Zhu, Jie, Cao, Jiayu, Leach, Andrew G., Liesz, Arthur, Freeman, Sally, Brough, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193008/
https://www.ncbi.nlm.nih.gov/pubmed/37216118
http://dx.doi.org/10.1016/j.isci.2023.106758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193008/
https://www.ncbi.nlm.nih.gov/pubmed/37216118
http://dx.doi.org/10.1016/j.isci.2023.106758

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