Cargando…
Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
Inflammation driven by DNA sensors is now understood to be important to disease pathogenesis. Here, we describe new inhibitors of DNA sensing, primarily of the inflammasome forming sensor AIM2. Biochemistry and molecular modeling has revealed 4-sulfonic calixarenes as potent inhibitors of AIM2 that...
Autores principales: | Green, Jack P., El-Sharkawy, Lina Y., Roth, Stefan, Zhu, Jie, Cao, Jiayu, Leach, Andrew G., Liesz, Arthur, Freeman, Sally, Brough, David |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193008/ https://www.ncbi.nlm.nih.gov/pubmed/37216118 http://dx.doi.org/10.1016/j.isci.2023.106758 |
Ejemplares similares
-
Inhibiting the NLRP3 Inflammasome
por: El-Sharkawy, Lina Y., et al.
Publicado: (2020) -
LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation
por: Green, Jack P, et al.
Publicado: (2020) -
A macrophage-T cell coculture model for severe tissue injury-induced T cell death
por: Zhu, Jie, et al.
Publicado: (2021) -
AIM2 Inflammasome's First Decade of Discovery: Focus on Oral Diseases
por: Wang, Lufei, et al.
Publicado: (2020) -
Inflammasome-independent functions of AIM2
por: Zhao, Junjie, et al.
Publicado: (2021)