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Nonstructural N- and C-tails of Dbp2 confer the protein full helicase activities

Human DDX5 and its yeast ortholog Dbp2 are ATP-dependent RNA helicases that play a key role in normal cell processes, cancer development, and viral infection. The crystal structure of the RecA1-like domain of DDX5 is available but the global structure of DDX5/Dbp2 subfamily proteins remains to be el...

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Detalles Bibliográficos
Autores principales: Song, Qin-Xia, Liu, Na-Nv, Liu, Zhao-Xia, Zhang, Ying-Zi, Rety, Stephane, Hou, Xi-Miao, Xi, Xu-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193013/
https://www.ncbi.nlm.nih.gov/pubmed/36894019
http://dx.doi.org/10.1016/j.jbc.2023.104592