A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCA

We report a novel small-molecule screening approach that combines data augmentation and machine learning to identify Food and Drug Administration (FDA)-approved drugs interacting with the calcium pump (Sarcoplasmic reticulum Ca(2+)-ATPase, SERCA) from skeletal (SERCA1a) and cardiac (SERCA2a) muscle....

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Detalles Bibliográficos
Autores principales: Cruz-Cortés, Carlos, Velasco-Saavedra, M. Andrés, Fernández-de Gortari, Eli, Guerrero-Serna, Guadalupe, Aguayo-Ortiz, Rodrigo, Espinoza-Fonseca, L. Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193016/
https://www.ncbi.nlm.nih.gov/pubmed/37030504
http://dx.doi.org/10.1016/j.jbc.2023.104681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193016/
https://www.ncbi.nlm.nih.gov/pubmed/37030504
http://dx.doi.org/10.1016/j.jbc.2023.104681

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