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A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCA
We report a novel small-molecule screening approach that combines data augmentation and machine learning to identify Food and Drug Administration (FDA)-approved drugs interacting with the calcium pump (Sarcoplasmic reticulum Ca(2+)-ATPase, SERCA) from skeletal (SERCA1a) and cardiac (SERCA2a) muscle....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193016/ https://www.ncbi.nlm.nih.gov/pubmed/37030504 http://dx.doi.org/10.1016/j.jbc.2023.104681 |