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TP53BP1, a dual-coding gene, uses promoter switching and translational reinitiation to express a smORF protein
The complexity of the metazoan proteome is significantly increased by the expression of small proteins (<100 aa) derived from smORFs within lncRNAs, uORFs, 3′ UTRs and, reading frames overlapping the CDS. These smORF encoded proteins (SEPs) have diverse roles, ranging from the regulation of cellu...
Autores principales: | Inchingolo, Marta A., Diman, Aurélie, Adamczewski, Maxime, Humphreys, Tom, Jaquier-Gubler, Pascale, Curran, Joseph A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193022/ https://www.ncbi.nlm.nih.gov/pubmed/37216125 http://dx.doi.org/10.1016/j.isci.2023.106757 |
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