Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids

BACKGROUND: High grade serous ovarian cancer (HGSOC) is highly lethal, partly due to chemotherapy resistance and limited availability of targeted approaches. Cyclin dependent kinases 12 and 13 (CDK12/13) are promising therapeutic targets in human cancers, including HGSOC. Nevertheless, the effects o...

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Detalles Bibliográficos
Autores principales: Cesari, Eleonora, Ciucci, Alessandra, Pieraccioli, Marco, Caggiano, Cinzia, Nero, Camilla, Bonvissuto, Davide, Sillano, Francesca, Buttarelli, Marianna, Piermattei, Alessia, Loverro, Matteo, Camarda, Floriana, Greco, Viviana, De Bonis, Maria, Minucci, Angelo, Gallo, Daniela, Urbani, Andrea, Vizzielli, Giuseppe, Scambia, Giovanni, Sette, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193743/
https://www.ncbi.nlm.nih.gov/pubmed/37202753
http://dx.doi.org/10.1186/s13046-023-02682-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193743/
https://www.ncbi.nlm.nih.gov/pubmed/37202753
http://dx.doi.org/10.1186/s13046-023-02682-5

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