Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19

Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe COVID-19 remains unidentified. Herein we demonstrate that the virus-encoded Open Reading Frame 8 (ORF8) protein is abundantly...

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Detalles Bibliográficos
Autores principales: Wu, Xiaosheng, Manske, Michelle K., Ruan, Gordon J., Witter, Taylor L., Nowakowski, Kevin E., Abeykoon, Jithma P., Tang, Xinyi, Yu, Yue, Gwin, Kimberly A., Wu, Annie, Taupin, Vanessa, Bhardwaj, Vaishali, Paludo, Jonas, Dasari, Surendra, Dong, Haidong, Ansell, Stephen M., Badley, Andrew D., Schellenberg, Matthew J., Witzig, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193824/
https://www.ncbi.nlm.nih.gov/pubmed/37260746
http://dx.doi.org/10.1016/j.isci.2023.106929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193824/
https://www.ncbi.nlm.nih.gov/pubmed/37260746
http://dx.doi.org/10.1016/j.isci.2023.106929

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