Discovery of dual S-RBD/NRP1-targeting peptides: structure-based virtual screening, synthesis, biological evaluation, and molecular dynamics simulation studies

Both receptor-binding domain in spike protein (S-RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human neuropilin-1 (NRP1) are important in the virus entry, and their concomitant inhibition may become a potential strategy against the SARS-CoV-2 infection. Herein, five novel...

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Detalles Bibliográficos
Autores principales: Hu, Chunfang, Guo, Ting, Zou, Yunting, Gao, Junyi, Gao, Yi, Niu, Miaomiao, Xia, Yang, Shen, Xiaozhou, Li, Jindong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193894/
https://www.ncbi.nlm.nih.gov/pubmed/37194732
http://dx.doi.org/10.1080/14756366.2023.2212327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193894/
https://www.ncbi.nlm.nih.gov/pubmed/37194732
http://dx.doi.org/10.1080/14756366.2023.2212327

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