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ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway

Bone marrow stromal antigen 2 (BST2)/tetherin is a restriction factor that reduces HIV-1 dissemination by tethering virus at the cell surface. BST2 also acts as a sensor of HIV-1 budding, establishing a cellular antiviral state. The HIV-1 Vpu protein antagonizes BST2 antiviral functions via multiple...

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Detalles Bibliográficos
Autores principales: Judith, Delphine, Versapuech, Margaux, Bejjani, Fabienne, Palaric, Marjory, Verlhac, Pauline, Kuster, Aurelia, Lepont, Leslie, Gallois-Montbrun, Sarah, Janvier, Katy, Berlioz-Torrent, Clarisse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193943/
https://www.ncbi.nlm.nih.gov/pubmed/37155854
http://dx.doi.org/10.1073/pnas.2217451120