A novel method to estimate the absorption rate constant for two-compartment model fitted drugs without intravenous pharmacokinetic data

The in vivo performances of most drugs after extravascular administration are fitted well with the two-compartment pharmacokinetic (PK) model, but the estimation of absorption rate constant (k(a)) for these drugs becomes difficult during unavailability of intravenous PK data. Herein, we developed a...

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Detalles Bibliográficos
Autores principales: Liu, Fan, Yi, Hanxi, Wang, Lei, Cheng, Zeneng, Zhang, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194656/
https://www.ncbi.nlm.nih.gov/pubmed/37214472
http://dx.doi.org/10.3389/fphar.2023.1087913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194656/
https://www.ncbi.nlm.nih.gov/pubmed/37214472
http://dx.doi.org/10.3389/fphar.2023.1087913

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