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Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with K(ATP) channel gain-of-function

Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits of K(ATP) channels. K(ATP) overactivity results in a chronic reduction in arterial tone and hypotension, leading to other systemic cardiovascular complications. However, t...

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Detalles Bibliográficos
Autores principales: Davis, Michael J, Castorena-Gonzalez, Jorge A, Kim, Hae Jin, Li, Min, Remedi, Maria, Nichols, Colin G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194823/
https://www.ncbi.nlm.nih.gov/pubmed/37214333
http://dx.doi.org/10.1093/function/zqad017